Engineered bacterium fuels evolution debate

Epigenetic noise fuels cancer evolution.

Cancer is a disease of the genome and the epigenome. Previous studies have shown that genomic changes such as mutations, copy number variation, and genomic rearrangements drive cancer evolution. In this issue of Cancer Cell, Landau and colleagues add epigenomic changes, specifically locally disordered DNA methylation, to cancer's evolutionary trajectory.

Epigenetic noise fuels cancer evolution

Deep genomic sequencing technologies are beginning to resolve the underlying complexities of solid and hematologic cancers. Peter Nowell’s proposed model for cancer evolution suggesting that cancers evolve through branched evolutionary trajectories fuelled by genomic instability is now increasingly being accepted as a basis for therapeutic failure and the increasing mismatch between cost and cl...

Running Title : Engineered bacterium inhibits tumor growth

The “Creationism vs. Evolution” Debate

For example, evolution states that at one point in time, a strain of fish began encountering mutations in its DNA, which eventually (after many generations) gave its descendants the ability to breathe air and to move around on the earth. As a result, those mutations caused that strain of fish to become frogs. Similarly, at some later point in time, a strain of frogs began encountering mutations...

Grammaticalization and language evolution: Focusing the debate

Reconstructions of the languages spoken by first modern humans based on grammaticalization theory rely on the assumption that the involved cognitive capacities and the motivations for grammaticalizing a language were the same in the past as today. Nonetheless, subtle changes in the brain and in behaviour have occurred during recent human history that might have affected early grammaticalization...